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Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases
The enzyme activation-induced deaminase (AID) targets the immunoglobulin loci in activated B cells and creates DNA mutations in the antigen-binding variable region and DNA breaks in the switch region through processes known, respectively, as somatic hypermutation and class switch recombination. AID...
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| Publicado no: | DNA Repair (Amst) |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4740194/ https://ncbi.nlm.nih.gov/pubmed/26719140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2015.11.011 |
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