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Different mutation signatures in DNA polymerase η- and MSH6-deficient mice suggest separate roles in antibody diversification
Hypermutation in immunoglobulin genes produces a high frequency of substitutions of all four bases, which are likely generated by low-fidelity DNA polymerases. Indeed, humans deficient for DNA polymerase (pol) η have decreased substitutions of A·T base pairs in variable and switch regions. To study...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1150827/ https://ncbi.nlm.nih.gov/pubmed/15939880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501852102 |
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