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MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes
Activation-induced cytidine deaminase deaminates cytosine to uracil (dU) in DNA, which leads to mutations at C:G basepairs in immunoglobulin genes during somatic hypermutation. The mechanism that generates mutations at A:T basepairs, however, remains unclear. It appears to require the MSH2–MSH6 mism...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2213055/ https://ncbi.nlm.nih.gov/pubmed/15710654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20042066 |
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