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DNA breaks in Ig V regions are predominantly single-stranded and are generated by UNG and MSH6 DNA repair pathways
Antibody diversity is initiated by activation-induced deaminase (AID), which deaminates cytosine to uracil in DNA. Uracils in the Ig gene loci can be recognized by uracil DNA glycosylase (UNG) or mutS homologs 2 and 6 (MSH2-MSH6) proteins, and then processed into DNA breaks. Breaks in switch regions...
Gardado en:
| Publicado en: | J Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6382588/ https://ncbi.nlm.nih.gov/pubmed/30665938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801183 |
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