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DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions
Low-fidelity DNA polymerases introduce nucleotide substitutions in immunoglobulin variable regions during somatic hypermutation. Although DNA polymerase (pol) η is the major low-fidelity polymerase, other DNA polymerases may also contribute. Existing data are contradictory as to whether pol ζ is inv...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3371727/ https://ncbi.nlm.nih.gov/pubmed/22615128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112234 |
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