Immunoglobulin switch μ sequence causes RNA polymerase II accumulation and reduces dA hypermutation

Repetitive DNA sequences in the immunoglobulin switch μ region form RNA-containing secondary structures and undergo hypermutation by activation-induced deaminase (AID). To examine how DNA structure affects transcription and hypermutation, we mapped the position of RNA polymerase II molecules and mut...

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Bibliographische Detailangaben
Hauptverfasser: Rajagopal, Deepa, Maul, Robert W., Ghosh, Amalendu, Chakraborty, Tirtha, Khamlichi, Ahmed Amine, Sen, Ranjan, Gearhart, Patricia J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2009
Schlagworte:
Brief Definitive Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715057/
https://ncbi.nlm.nih.gov/pubmed/19433618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082514
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