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S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

Endothelial nitric oxide synthase (eNOS) is critical in the regulation of vascular function, and can generate both nitric oxide (NO) and superoxide (O(2)(•−)), which are key mediators of cellular signalling. In the presence of Ca(2+)/calmodulin, eNOS produces NO, endothelial-derived relaxing factor,...

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Autors principals: Chen, Chun-An, Wang, Tse-Yao, Varadharaj, Saradhadevi, Reyes, Levy A., Hemann, Craig, Hassan Talukder, M. A., Chen, Yeong-Renn, Druhan, Lawrence J., Zweier, Jay L.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370391/
https://ncbi.nlm.nih.gov/pubmed/21179168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09599
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