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Chimeric antigen receptor (CAR) T cells shape myeloid cell function within the tumor microenvironment through IFN-γ and GM-CSF

The infiltration of suppressive myeloid cells into the tumor microenvironment restrains anti-tumor immunity. However, cytokines may alter the function of myeloid lineage cells to support tumor rejection, regulating the balance between pro- and anti-tumor immunity. In this study, it is shown that eff...

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Detalhes bibliográficos
Main Authors: Spear, Paul, Barber, Amorette, Rynda-Apple, Agnieszka, Sentman, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370144/
https://ncbi.nlm.nih.gov/pubmed/22586039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103019
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