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Chimeric NKG2D expressing T cells eliminate immunosuppression and activate immunity within the ovarian tumor microenvironment
Adoptive transfer of T cells expressing chimeric NKG2D receptors (chNKG2D), a fusion of NKG2D and CD3ζ, can lead to long-term, tumor-free surv ival in a murine model of ovarian cancer. To determine the mechanisms of chNKG2D T cell anti-tumor efficacy, we analyzed how chNKG2D T cells altered the tumo...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825039/ https://ncbi.nlm.nih.gov/pubmed/19915047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902000 |
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