Collaboration of chimeric antigen receptor (CAR)-expressing T cells and host T cells for optimal elimination of established ovarian tumors

Conditioning strategies that deplete host lymphocytes have been shown to enhance clinical responses to some adoptive T-cell therapies. However, host T cells are capable of eliminating tumor cells upon the relief of immunosuppression, indicating that lymphodepletion prior to T-cell transfer may reduc...

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Bibliographic Details
Main Authors: Spear, Paul, Barber, Amorette, Sentman, Charles L.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654581/
https://ncbi.nlm.nih.gov/pubmed/23734311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.23564
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