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Chimeric NKG2D T cells require both T cell- and host-derived cytokine secretion and perforin expression to increase tumor antigen presentation and systemic immunity
Treatment of mice bearing established ovarian tumors with T cells expressing chimeric NKG2D receptors (chNKG2D) develop protective host immune responses to tumor antigens. In this study, the mechanisms that chNKG2D T cells require to induce host immunity against ovarian tumors and which of the host...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825035/ https://ncbi.nlm.nih.gov/pubmed/19625653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900721 |
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