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Chimeric NKG2D T cells require both T cell- and host-derived cytokine secretion and perforin expression to increase tumor antigen presentation and systemic immunity

Treatment of mice bearing established ovarian tumors with T cells expressing chimeric NKG2D receptors (chNKG2D) develop protective host immune responses to tumor antigens. In this study, the mechanisms that chNKG2D T cells require to induce host immunity against ovarian tumors and which of the host...

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Bibliografiske detaljer
Main Authors: Barber, Amorette, Sentman, Charles L.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825035/
https://ncbi.nlm.nih.gov/pubmed/19625653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900721
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