Tuning the Drug Efflux Activity of an ABC Transporter in vivo by in vitro Selected DARPin Binders

ABC transporters use the energy from binding and hydrolysis of ATP to import or extrude substrates across the membrane. Using ribosome display, we raised designed ankyrin repeat proteins (DARPins) against detergent solubilized LmrCD, a heterodimeric multidrug ABC exporter from Lactococcus lactis. Se...

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Bibliografiske detaljer
Main Authors: Seeger, Markus A., Mittal, Anshumali, Velamakanni, Saroj, Hohl, Michael, Schauer, Stefan, Salaa, Ihsene, Grütter, Markus G., van Veen, Hendrik W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366976/
https://ncbi.nlm.nih.gov/pubmed/22675494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037845
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