Tuning the Drug Efflux Activity of an ABC Transporter in vivo by in vitro Selected DARPin Binders

ABC transporters use the energy from binding and hydrolysis of ATP to import or extrude substrates across the membrane. Using ribosome display, we raised designed ankyrin repeat proteins (DARPins) against detergent solubilized LmrCD, a heterodimeric multidrug ABC exporter from Lactococcus lactis. Se...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Seeger, Markus A., Mittal, Anshumali, Velamakanni, Saroj, Hohl, Michael, Schauer, Stefan, Salaa, Ihsene, Grütter, Markus G., van Veen, Hendrik W.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366976/
https://ncbi.nlm.nih.gov/pubmed/22675494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037845
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires