Tuning the Drug Efflux Activity of an ABC Transporter in vivo by in vitro Selected DARPin Binders

ABC transporters use the energy from binding and hydrolysis of ATP to import or extrude substrates across the membrane. Using ribosome display, we raised designed ankyrin repeat proteins (DARPins) against detergent solubilized LmrCD, a heterodimeric multidrug ABC exporter from Lactococcus lactis. Se...

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Autores principales: Seeger, Markus A., Mittal, Anshumali, Velamakanni, Saroj, Hohl, Michael, Schauer, Stefan, Salaa, Ihsene, Grütter, Markus G., van Veen, Hendrik W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366976/
https://ncbi.nlm.nih.gov/pubmed/22675494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037845
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