Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

Mammalian target of rapamycin complex 1 (mTORC1) signaling is frequently dysregulated in cancer. Inhibition of mTORC1 is thus regarded as a promising strategy in the treatment of tumors with elevated mTORC1 activity. We have recently identified niclosamide (a Food and Drug Administration-approved an...

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Main Authors: Fonseca, Bruno D., Diering, Graham H., Bidinosti, Michael A., Dalal, Kush, Alain, Tommy, Balgi, Aruna D., Forestieri, Roberto, Nodwell, Matt, Rajadurai, Charles V., Gunaratnam, Cynthia, Tee, Andrew R., Duong, Franck, Andersen, Raymond J., Orlowski, John, Numata, Masayuki, Sonenberg, Nahum, Roberge, Michel
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366846/
https://ncbi.nlm.nih.gov/pubmed/22474287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359638
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