Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation

Glucocorticoids acting through the glucocorticoid receptor (GR) inhibit TNF-induced lethal inflammation. Here, we demonstrate that GR dimerization plays a role in reducing TNF sensitivity. In mutant mice unable to dimerize GR, we found that TNF failed to induce MAPK phosphatase 1 (MKP1). We assessed...

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Autori principali: Vandevyver, Sofie, Dejager, Lien, Van Bogaert, Tom, Kleyman, Anna, Liu, Yusen, Tuckermann, Jan, Libert, Claude
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366401/
https://ncbi.nlm.nih.gov/pubmed/22585571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60006
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