Tumor Necrosis Factor Inhibits Glucocorticoid Receptor Function in Mice: A STRONG SIGNAL TOWARD LETHAL SHOCK

As glucocorticoid resistance (GCR) and the concomitant burden pose a worldwide problem, there is an urgent need for a more effective glucocorticoid therapy, for which insights into the molecular mechanisms of GCR are essential. In this study, we addressed the hypothesis that TNFα, a strong pro-infla...

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Bibliographische Detailangaben
Hauptverfasser: Van Bogaert, Tom, Vandevyver, Sofie, Dejager, Lien, Van Hauwermeiren, Filip, Pinheiro, Iris, Petta, Ioanna, Engblom, David, Kleyman, Anna, Schütz, Günther, Tuckermann, Jan, Libert, Claude
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143620/
https://ncbi.nlm.nih.gov/pubmed/21646349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.212365
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