Type I interferon drives tumor necrosis factor–induced lethal shock

Tumor necrosis factor (TNF) is reputed to have very powerful antitumor effects, but it is also a strong proinflammatory cytokine. Injection of TNF in humans and mice leads to a systemic inflammatory response syndrome with major effects on liver and bowels. TNF is also a central mediator in several i...

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Detalhes bibliográficos
Main Authors: Huys, Liesbeth, Van Hauwermeiren, Filip, Dejager, Lien, Dejonckheere, Eline, Lienenklaus, Stefan, Weiss, Siegfried, Leclercq, Georges, Libert, Claude
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737160/
https://ncbi.nlm.nih.gov/pubmed/19687227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090213
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