Zinc inhibits lethal inflammatory shock by preventing microbe‐induced interferon signature in intestinal epithelium

The cytokine TNF drives inflammatory diseases, e.g., Crohn's disease. In a mouse model of TNF‐induced systemic inflammatory response syndrome (SIRS), severe impact on intestinal epithelial cells (IECs) is observed. Zinc confers complete protection in this model. We found that zinc no longer pro...

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Publicat a:EMBO Mol Med
Autors principals: Souffriau, Jolien, Timmermans, Steven, Vanderhaeghen, Tineke, Wallaeys, Charlotte, Van Looveren, Kelly, Aelbrecht, Lindsy, Dewaele, Sylviane, Vandewalle, Jolien, Goossens, Evy, Verbanck, Serge, Boyen, Filip, Eggermont, Melanie, De Commer, Lindsey, De Rycke, Riet, De Bruyne, Michiel, Tito, Raul, Ballegeer, Marlies, Vandevyver, Sofie, Velho, Tiago, Moita, Luis Ferreira, Hochepied, Tino, De Bosscher, Karolien, Raes, Jeroen, Van Immerseel, Filip, Beyaert, Rudi, Libert, Claude
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539219/
https://ncbi.nlm.nih.gov/pubmed/32914580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201911917
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