A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation

It has been suggested that glucocorticoid receptor (GR) agonists that promote GR homodimerization more than standard glucocorticoids such as Dexamethasone could be more effective anti-inflammatory molecules against acute and life-threatening inflammatory conditions. To test this hypothesis, we set u...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Souffriau, Jolien, Eggermont, Melanie, Van Ryckeghem, Sara, Van Looveren, Kelly, Van Wyngene, Lise, Van Hamme, Evelien, Vuylsteke, Marnik, Beyaert, Rudi, De Bosscher, Karolien, Libert, Claude
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110732/
https://ncbi.nlm.nih.gov/pubmed/30150712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31150-w
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