Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

TNF is an important mediator in numerous inflammatory diseases, e.g., in inflammatory bowel diseases (IBDs). In IBD, acute increases in TNF production can lead to disease flares. Glucocorticoids (GCs), which are steroids that bind and activate the glucocorticoid receptor (GR), are able to protect an...

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Publicado en:J Clin Invest
Autores principales: Ballegeer, Marlies, Van Looveren, Kelly, Timmermans, Steven, Eggermont, Melanie, Vandevyver, Sofie, Thery, Fabien, Dendoncker, Karen, Souffriau, Jolien, Vandewalle, Jolien, Van Wyngene, Lise, De Rycke, Riet, Takahashi, Nozomi, Vandenabeele, Peter, Tuckermann, Jan, Reichardt, Holger M., Impens, Francis, Beyaert, Rudi, De Bosscher, Karolien, Vandenbroucke, Roosmarijn E., Libert, Claude
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063488/
https://ncbi.nlm.nih.gov/pubmed/29746256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96636
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