TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Glucocorticoid resistance (GCR) is defined as an unresponsiveness to the therapeutic effects, including the antiinflammatory ones of glucocorticoids (GCs) and their receptor, the glucocorticoid receptor (GR). It is a problem in the management of inflammatory diseases and can be congenital as well as...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Dendoncker, Karen, Timmermans, Steven, Vandewalle, Jolien, Eggermont, Melanie, Lempiäinen, Joanna, Van Hamme, Evelien, Dewaele, Sylviane, Vandevyver, Sofie, Ballegeer, Marlies, Souffriau, Jolien, Van Wyngene, Lise, Van Looveren, Kelly, Vanderhaeghen, Tineke, Beyaert, Rudi, De Bosscher, Karolien, Palvimo, Jorma J., Van Montagu, Marc, Libert, Claude
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600915/
https://ncbi.nlm.nih.gov/pubmed/31182584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821565116
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