TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Glucocorticoid resistance (GCR) is defined as an unresponsiveness to the therapeutic effects, including the antiinflammatory ones of glucocorticoids (GCs) and their receptor, the glucocorticoid receptor (GR). It is a problem in the management of inflammatory diseases and can be congenital as well as...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Dendoncker, Karen, Timmermans, Steven, Vandewalle, Jolien, Eggermont, Melanie, Lempiäinen, Joanna, Van Hamme, Evelien, Dewaele, Sylviane, Vandevyver, Sofie, Ballegeer, Marlies, Souffriau, Jolien, Van Wyngene, Lise, Van Looveren, Kelly, Vanderhaeghen, Tineke, Beyaert, Rudi, De Bosscher, Karolien, Palvimo, Jorma J., Van Montagu, Marc, Libert, Claude
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600915/
https://ncbi.nlm.nih.gov/pubmed/31182584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821565116
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