TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Glucocorticoid resistance (GCR) is defined as an unresponsiveness to the therapeutic effects, including the antiinflammatory ones of glucocorticoids (GCs) and their receptor, the glucocorticoid receptor (GR). It is a problem in the management of inflammatory diseases and can be congenital as well as...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Dendoncker, Karen, Timmermans, Steven, Vandewalle, Jolien, Eggermont, Melanie, Lempiäinen, Joanna, Van Hamme, Evelien, Dewaele, Sylviane, Vandevyver, Sofie, Ballegeer, Marlies, Souffriau, Jolien, Van Wyngene, Lise, Van Looveren, Kelly, Vanderhaeghen, Tineke, Beyaert, Rudi, De Bosscher, Karolien, Palvimo, Jorma J., Van Montagu, Marc, Libert, Claude
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600915/
https://ncbi.nlm.nih.gov/pubmed/31182584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821565116
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