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Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation
Glucocorticoids acting through the glucocorticoid receptor (GR) inhibit TNF-induced lethal inflammation. Here, we demonstrate that GR dimerization plays a role in reducing TNF sensitivity. In mutant mice unable to dimerize GR, we found that TNF failed to induce MAPK phosphatase 1 (MKP1). We assessed...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366401/ https://ncbi.nlm.nih.gov/pubmed/22585571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60006 |
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