Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation

Glucocorticoids acting through the glucocorticoid receptor (GR) inhibit TNF-induced lethal inflammation. Here, we demonstrate that GR dimerization plays a role in reducing TNF sensitivity. In mutant mice unable to dimerize GR, we found that TNF failed to induce MAPK phosphatase 1 (MKP1). We assessed...

Full description

Saved in:
Bibliographic Details
Main Authors: Vandevyver, Sofie, Dejager, Lien, Van Bogaert, Tom, Kleyman, Anna, Liu, Yusen, Tuckermann, Jan, Libert, Claude
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366401/
https://ncbi.nlm.nih.gov/pubmed/22585571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60006
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items