A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers

Cancer cells subvert the natural balance between cellular life and death, achieving immortality through pathologic enforcement of survival pathways and blockade of cell death mechanisms. Pro-apoptotic BCL-2 family proteins are frequently disarmed in relapsed and refractory cancer through genetic del...

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Autors principals: LaBelle, James L., Katz, Samuel G., Bird, Gregory H., Gavathiotis, Evripidis, Stewart, Michelle L., Lawrence, Chelsea, Fisher, Jill K., Godes, Marina, Pitter, Kenneth, Kung, Andrew L., Walensky, Loren D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366394/
https://ncbi.nlm.nih.gov/pubmed/22622039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46231
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