The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

Nonalcoholic fatty liver disease (NAFLD) is associated with all features of the metabolic syndrome. Although deposition of excess triglycerides within liver cells, a hallmark of NAFLD, is associated with a loss of insulin sensitivity, it is not clear which cellular abnormality arises first. We have...

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Detalhes bibliográficos
Main Authors: Benhamed, Fadila, Denechaud, Pierre-Damien, Lemoine, Maud, Robichon, Céline, Moldes, Marthe, Bertrand-Michel, Justine, Ratziu, Vlad, Serfaty, Lawrence, Housset, Chantal, Capeau, Jacqueline, Girard, Jean, Guillou, Hervé, Postic, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366390/
https://ncbi.nlm.nih.gov/pubmed/22546860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41636
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