Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation

Dietary polyunsaturated fatty acids (PUFAs) are potent inhibitors of hepatic glycolysis and lipogenesis. Recently, carbohydrate-responsive element–binding protein (ChREBP) was implicated in the regulation by glucose of glycolytic and lipogenic genes, including those encoding L-pyruvate kinase (L-PK)...

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Autores principales: Dentin, Renaud, Benhamed, Fadila, Pégorier, Jean-Paul, Foufelle, Fabienne, Viollet, Benoit, Vaulont, Sophie, Girard, Jean, Postic, Catherine
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2005
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224299/
https://ncbi.nlm.nih.gov/pubmed/16184193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25256
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