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Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

Obesity and type 2 diabetes are associated with increased lipogenesis in the liver. This results in fat accumulation in hepatocytes, a condition known as hepatic steatosis, which is a form of nonalcoholic fatty liver disease (NAFLD), the most common cause of liver dysfunction in the United States. C...

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Detalhes bibliográficos
Main Authors: Bricambert, Julien, Miranda, Jonatan, Benhamed, Fadila, Girard, Jean, Postic, Catherine, Dentin, Renaud
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993582/
https://ncbi.nlm.nih.gov/pubmed/21084751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41624
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