The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice

OBJECTIVE: Glucose production in the blood requires the expression of glucose-6 phosphatase (G6Pase), a key enzyme that allows glucose-6 phosphate (G6P) hydrolysis into free glucose and inorganic phosphate. We previously reported that the hepatic suppression of G6Pase leads to G6P accumulation and t...

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Publicat a:Mol Metab
Autors principals: Rajas, Fabienne, Dentin, Renaud, Cannella Miliano, Alexane, Silva, Marine, Raffin, Margaux, Levavasseur, Françoise, Gautier-Stein, Amandine, Postic, Catherine, Mithieux, Gilles
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691719/
https://ncbi.nlm.nih.gov/pubmed/33137488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101108
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