Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice

Disruption of the Pex2 gene leads to peroxisome deficiency and widespread metabolic dysfunction. We previously demonstrated that peroxisomes are critical for maintaining cholesterol homeostasis, using peroxisome-deficient Pex2(−/−) mice on a hybrid Swiss Webster×129S6/SvEv (SW/129) genetic backgroun...

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Hlavní autoři: Kovacs, Werner J., Charles, Khanichi N., Walter, Katharina M., Shackelford, Janis E., Wikander, Thomas M., Richards, Michael J., Fliesler, Steven J., Krisans, Skaidrite K., Faust, Phyllis L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366256/
https://ncbi.nlm.nih.gov/pubmed/22441164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2012.02.011
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