Disturbed Cholesterol Homeostasis in a Peroxisome-Deficient PEX2 Knockout Mouse Model

We evaluated the major pathways of cholesterol regulation in the peroxisome-deficient PEX2(−/−) mouse, a model for Zellweger syndrome. Zellweger syndrome is a lethal inherited disorder characterized by severe defects in peroxisome biogenesis and peroxisomal protein import. Compared with wild-type mi...

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Detalhes bibliográficos
Main Authors: Kovacs, Werner J., Shackelford, Janis E., Tape, Khanichi N., Richards, Michael J., Faust, Phyllis L., Fliesler, Steven J., Krisans, Skaidrite K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC303355/
https://ncbi.nlm.nih.gov/pubmed/14673138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.1.1-13.2004
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