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Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice
Disruption of the Pex2 gene leads to peroxisome deficiency and widespread metabolic dysfunction. We previously demonstrated that peroxisomes are critical for maintaining cholesterol homeostasis, using peroxisome-deficient Pex2(−/−) mice on a hybrid Swiss Webster×129S6/SvEv (SW/129) genetic backgroun...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366256/ https://ncbi.nlm.nih.gov/pubmed/22441164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2012.02.011 |
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