Загрузка...

Molecular Basis for Binding and Subtype Selectivity of 1,4-Benzodiazepine Antagonist Ligands of the Cholecystokinin Receptor

Allosteric binding pockets in peptide-binding G protein-coupled receptors create opportunities for the development of small molecule drugs with substantial benefits over orthosteric ligands. To gain insights into molecular determinants for this pocket within type 1 and 2 cholecystokinin receptors (C...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Cawston, Erin E., Lam, Polo C. H., Harikumar, Kaleeckal G., Dong, Maoqing, Ball, Alicja M., Augustine, Mary Lou, Akgün, Eyup, Portoghese, Philip S., Orry, Andrew, Abagyan, Ruben, Sexton, Patrick M., Miller, Laurence J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365725/
https://ncbi.nlm.nih.gov/pubmed/22467877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.335646
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!