Functional analysis of the protein phosphatase activity of PTEN

In vitro, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) displays intrinsic phosphatase activity towards both protein and lipid substrates. In vivo, the lipid phosphatase activity of PTEN, through which it dephosphorylates the 3 position in the inositol sugar...

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Bibliographic Details
Main Authors: Zhang, Xiaoqun Catherine, Piccini, Antonella, Myers, Michael P., Van Aelst, Linda, Tonks, Nicholas K.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365644/
https://ncbi.nlm.nih.gov/pubmed/22413754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120098
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