PTEN inhibits BMI1 function independently of its phosphatase activity

BACKGROUND: PTEN is the second most mutated tumor suppressor gene other than p53. It suppresses tumorigenesis by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate (PIP3) to phosphatidylinositol (4,5)-biphosphate (PIP2), thereby directly inhibiting phosphatidylinositol 3 kinase (PI3K)-media...

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Detalhes bibliográficos
Main Authors: Fan, Catherine, He, Lizhi, Kapoor, Anil, Rybak, Adrian P, De Melo, Jason, Cutz, Jean-Claude, Tang, Damu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777864/
https://ncbi.nlm.nih.gov/pubmed/19903340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-98
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