The lipid phosphatase activity of PTEN is critical for its tumor supressor function

Since their discovery, protein tyrosine phosphatases have been speculated to play a role in tumor suppression because of their ability to antagonize the growth-promoting protein tyrosine kinases. Recently, a tumor suppressor from human chromosome 10q23, called PTEN or MMAC1, has been identified that...

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Autori principali: Myers, Michael P., Pass, Ian, Batty, Ian H., Van der Kaay, Jeroen, Stolarov, Javor P., Hemmings, Brian A., Wigler, Michael H., Downes, C. Peter, Tonks, Nicholas K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1998
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC24850/
https://ncbi.nlm.nih.gov/pubmed/9811831
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