Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity

Mice with T-cell–specific loss of the tumor suppressor gene PTEN early in T-cell ontogeny develop thymic lymphomas that invariably harbor a reciprocal translocation involving the T-cell receptor α/δ locus and c-myc, t(14;15). In addition to its known function as a lipid phosphatase opposing PI3K sig...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Newton, Ryan H., Lu, Yu, Papa, Antonella, Whitcher, Greg H., Kang, Youn-Jung, Yan, Catherine, Pandolfi, Pier Paolo, Turka, Laurence A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729535/
https://ncbi.nlm.nih.gov/pubmed/25477498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-571372
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker