Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity

Mice with T-cell–specific loss of the tumor suppressor gene PTEN early in T-cell ontogeny develop thymic lymphomas that invariably harbor a reciprocal translocation involving the T-cell receptor α/δ locus and c-myc, t(14;15). In addition to its known function as a lipid phosphatase opposing PI3K sig...

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Bibliographic Details
Published in:Blood
Main Authors: Newton, Ryan H., Lu, Yu, Papa, Antonella, Whitcher, Greg H., Kang, Youn-Jung, Yan, Catherine, Pandolfi, Pier Paolo, Turka, Laurence A.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2015
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729535/
https://ncbi.nlm.nih.gov/pubmed/25477498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-571372
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