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Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity
Mice with T-cell–specific loss of the tumor suppressor gene PTEN early in T-cell ontogeny develop thymic lymphomas that invariably harbor a reciprocal translocation involving the T-cell receptor α/δ locus and c-myc, t(14;15). In addition to its known function as a lipid phosphatase opposing PI3K sig...
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| Publié dans: | Blood |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4729535/ https://ncbi.nlm.nih.gov/pubmed/25477498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-571372 |
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