Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies

The γ-secretase complex, composed of presenilin, anterior-pharynx-defective 1, nicastrin, and presenilin enhancer 2, catalyzes the intramembranous processing of a wide variety of type I membrane proteins, including amyloid precursor protein (APP) and Notch. Earlier studies have revealed that nicastr...

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Bibliografiske detaljer
Main Authors: Zhang, Xulun, Hoey, Robert J., Lin, Guoqing, Koide, Akiko, Leung, Brenda, Ahn, Kwangwook, Dolios, Georgia, Paduch, Marcin, Ikeuchi, Takeshi, Wang, Rong, Li, Yue-Ming, Koide, Shohei, Sisodia, Sangram S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365189/
https://ncbi.nlm.nih.gov/pubmed/22586122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202691109
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