Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids

Infectious prions containing the pathogenic conformer of the mammalian prion protein (PrP(Sc)) can be produced de novo from a mixture of the normal conformer (PrP(C)) with RNA and lipid molecules. Recent reconstitution studies indicate that nucleic acids are not required for the propagation of mouse...

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Bibliografiske detaljer
Main Authors: Deleault, Nathan R., Piro, Justin R., Walsh, Daniel J., Wang, Fei, Ma, Jiyan, Geoghegan, James C., Supattapone, Surachai
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365173/
https://ncbi.nlm.nih.gov/pubmed/22586108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204498109
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