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Phosphatidylethanolamine as a prion cofactor: Potential implications for disease pathogenesis

Mammalian prions with significant levels of specific infectivity can be formed in vitro from mixtures of prion protein (PrP) and cofactor molecules, but not from PrP alone. We recently isolated and identified the essential membrane phospholipid phosphatidylethanolamine (PE) as an endogenous cofactor...

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Autore principale: Supattapone, Surachai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510863/
https://ncbi.nlm.nih.gov/pubmed/22895101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.21826
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