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EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours

Missense mutations in TP53 gene promote metastasis in human tumours. However, little is known about the complete loss of function of p53 in tumour metastasis. Here we show that squamous cell carcinomas generated by the specific ablation of Trp53 gene in mouse epidermis are highly metastatic. Biochem...

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Xehetasun bibliografikoak
Egile Nagusiak: Bornachea, Olga, Santos, Mirentxu, Martínez-Cruz, Ana Belén, García-Escudero, Ramón, Dueñas, Marta, Costa, Clotilde, Segrelles, Carmen, Lorz, Corina, Buitrago, Agueda, Saiz-Ladera, Cristina, Agirre, Xabier, Grande, Teresa, Paradela, Beatriz, Maraver, Antonio, Ariza, José M., Prosper, Felipe, Serrano, Manuel, Sánchez-Céspedes, Montse, Paramio, Jesús M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364492/
https://ncbi.nlm.nih.gov/pubmed/22666537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00434
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