The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior

The TP63 gene codes for two major isoform types, TAp63 and ΔNp63, with probable opposite roles in tumorigenesis. The ΔNp63α protein is frequently amplified and overexpressed in different epithelial tumors. Accordingly, it has been considered a potential oncogene. Nonetheless, a possible metastatic s...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Bornachea, Olga, López-Calderón, Fernando F., Dueñas, Marta, Segrelles, Carmen, Lorz, Corina, Suárez-Cabrera, Cristian, Marañón, María, Paradela-Dobarro, Beatriz, Santos, Mirentxu, Paramio, Jesús M.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695182/
https://ncbi.nlm.nih.gov/pubmed/26203771
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