The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior

The TP63 gene codes for two major isoform types, TAp63 and ΔNp63, with probable opposite roles in tumorigenesis. The ΔNp63α protein is frequently amplified and overexpressed in different epithelial tumors. Accordingly, it has been considered a potential oncogene. Nonetheless, a possible metastatic s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Bornachea, Olga, López-Calderón, Fernando F., Dueñas, Marta, Segrelles, Carmen, Lorz, Corina, Suárez-Cabrera, Cristian, Marañón, María, Paradela-Dobarro, Beatriz, Santos, Mirentxu, Paramio, Jesús M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695182/
https://ncbi.nlm.nih.gov/pubmed/26203771
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge