Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma is a common human neoplasia with poor prognosis and survival that frequently display Akt overactivation. Here we show that mice displaying constitutive Akt activity (myrAkt) in combination with Trp53 loss in stratified epithelia develop oral cavity tumors that p...

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Detalhes bibliográficos
Main Authors: Moral, Marta, Segrelles, Carmen, Lara, M. Fernanda, Martinez-Cruz, Ana Belen, Lorz, Corina, Santos, Mirentxu, Garcia-Escudero, Ramon, Lu, Jerry, Kiguchi, Kaoru, Buitrago, Agueda, Costa, Clotilde, Saiz, Cristina, Rodriguez-Peralto, Jose L, Martinez-Tello, Francisco J, Rodriguez-Pinilla, Maria, Sanchez-Cespedes, Montserrat, Garin, Marina, Grande, Teresa, Bravo, Ana, DiGiovanni, John, Paramio, Jesus M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914485/
https://ncbi.nlm.nih.gov/pubmed/19176372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3240
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