Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma is a common human neoplasia with poor prognosis and survival that frequently display Akt overactivation. Here we show that mice displaying constitutive Akt activity (myrAkt) in combination with Trp53 loss in stratified epithelia develop oral cavity tumors that p...

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Autors principals: Moral, Marta, Segrelles, Carmen, Lara, M. Fernanda, Martinez-Cruz, Ana Belen, Lorz, Corina, Santos, Mirentxu, Garcia-Escudero, Ramon, Lu, Jerry, Kiguchi, Kaoru, Buitrago, Agueda, Costa, Clotilde, Saiz, Cristina, Rodriguez-Peralto, Jose L, Martinez-Tello, Francisco J, Rodriguez-Pinilla, Maria, Sanchez-Cespedes, Montserrat, Garin, Marina, Grande, Teresa, Bravo, Ana, DiGiovanni, John, Paramio, Jesus M.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914485/
https://ncbi.nlm.nih.gov/pubmed/19176372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3240
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