A Novel Tumor suppressor network in squamous malignancies

The specific ablation of Rb1 gene in stratified epithelia (Rb(F/F);K14cre) promotes proliferation and altered differentiation but is insufficient to produce spontaneous tumors. The pRb relative, p107, compensates some of the functions of pRb in these tissues; however, Rb(F/F);K14cre;p107(−/−) mice d...

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Main Authors: Costa, Clotilde, Santos, Mirentxu, Segrelles, Carmen, Dueñas, Marta, Lara, M. Fernanda, Agirre, Xabier, Prosper, Felipe, García-Escudero, Ramón, Paramio, Jesús M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494016/
https://ncbi.nlm.nih.gov/pubmed/23145321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00828
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