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Selective Cytotoxicity of Rhodium Metalloinsertors in Mismatch Repair-Deficient Cells()

Mismatches in DNA occur naturally during replication and as a result of endogenous DNA damaging agents, but the mismatch repair (MMR) pathway acts to correct mismatches before subsequent rounds of replication. Rhodium metalloinsertors bind to DNA mismatches with high affinity and specificity and rep...

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Bibliographic Details
Main Authors: Ernst, Russell J., Komor, Alexis C., Barton, Jacqueline K.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364161/
https://ncbi.nlm.nih.gov/pubmed/22103240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2015822
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