A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding

Proton-coupled folate transporter (PCFT) mediates folate intestinal absorption and transport across the choroid plexus, processes defective in subjects with hereditary folate malabsorption (HFM). PCFT is also widely expressed in human solid tumors where it contributes to the transport of pemetrexed...

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Detalhes bibliográficos
Main Authors: Shin, Daniel Sanghoon, Zhao, Rongbao, Yap, Enghui H., Fiser, Andras, Goldman, I. David
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Membrane Transporters, Ion Channels and Pumps
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361945/
https://ncbi.nlm.nih.gov/pubmed/22345511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00435.2011
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