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Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption

The proton-coupled folate transporter (PCFT-SLC46A1) is required for intestinal folate absorption and is mutated in the autosomal recessive disorder, hereditary folate malabsorption (HFM). This report characterizes properties and requirements of the R376 residue in PCFT function, including a R376Q m...

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Bibliografske podrobnosti
Main Authors: Mahadeo, Kris, Diop-Bove, Ndeye, Shin, Daniel, Unal, Ersin Selcuk, Teo, Juliana, Zhao, Rongbao, Chang, Min-Hwang, Fulterer, Andreas, Romero, Michael F., Goldman, I. David
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2010
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980313/
https://ncbi.nlm.nih.gov/pubmed/20686069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00113.2010
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