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Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption

The proton-coupled folate transporter (PCFT; SLC46A1) mediates folate transport into enterocytes in the proximal small intestine; pcft loss-of-function mutations are the basis for hereditary folate malabsorption. The current study explored the roles of Asp residues in PCFT function. A novel, homozyg...

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Библиографические подробности
Главные авторы: Shin, Daniel Sanghoon, Min, Sang Hee, Russell, Laura, Zhao, Rongbao, Fiser, Andras, Goldman, I. David
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012536/
https://ncbi.nlm.nih.gov/pubmed/20805364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-06-291237
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