Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS

The compositional and conformational changes during catalytic activation of the spliceosome promoted by the DEAH box ATPase Prp2 are only poorly understood. Here, we show by dual-color fluorescence cross-correlation spectroscopy (dcFCCS) that the binding affinity of several proteins is significantly...

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Detalhes bibliográficos
Main Authors: Ohrt, Thomas, Prior, Mira, Dannenberg, Julia, Odenwälder, Peter, Dybkov, Olexandr, Rasche, Nicolas, Schmitzová, Jana, Gregor, Ingo, Fabrizio, Patrizia, Enderlein, Jörg, Lührmann, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358646/
https://ncbi.nlm.nih.gov/pubmed/22535589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.033316.112
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